Targeting M-current: A new precision medicine approach in Dravet syndrome
Stefano Iavarone, Nikolas Layer, Carmine Ostacolo, Francesco Miceli, Maurizio Taglialatela, Holger Lerche, Thomas Wuttke, Ulrike B.S. Hedrich · FENS Forum 2024
Dravet Syndrome is a developmental and epileptic encephalopathy, with intractable seizures and other comorbidities; due to loss of function variants in SCN1A, the disease mostly manifests because of the impairment of the functionality of inhibitory interneurons. Trying to address the unmet clinical needs of patients carrying missense variants, we used a transgenic mouse model carrying the recurrent variant p.(Ala1783Val) in Scn1a. This mouse closely recapitulates the clinical phenotype, allowing to more deeply explore the epileptogenesis and find new precision medicine approaches.We carried ou
ePoster · Neuroscience