Investigating MBD5 protein and its contribution to PR-DUB complex in the developing brain
Firuze Unlu Bektas, Robert Illingworth · FENS Forum 2024
Epigenetic mechanisms are leveraged throughout development to maintain gene activity states. The polycomb group family of proteins are an essential class of epigenetic regulator, critical for neurodevelopment. Polycomb Repressive Complex 1 alters chromatin through the deposition of H2A ubiquitination(H2AK119ub1), in contrast, Polycomb repressive deubiquitinase (PR-DUB) complex removes H2AK119ub1. The antagonistic relationship maintains the appropriate balance of H2AK119ub within the cell to control gene expression. MBD5 plays an important role in stabilizing the PR-DUB. Mutations in MBD5 gene
ePoster · Neuroscience