Accelerated epigenetic aging involves Polycomb group proteins in Huntington’s disease
Baptiste Brulé, Rafael Alcalá-Vida, Noémie Penaud, Jil Scuto, Charles Decraene, Stéphanie Le Gras, Brigitte Cosquer, Anne-Laurence Boutillier, Karine Merienne · FENS Forum 2024
With age, differentiated cells undergo a progressive erosion of epigenetic landscape and loss of cellular identity. Specifically, epigenetic aging involves H3K27ac depletion at cellular identity genes and their subsequent repression, together with H3K27me3-mediated derepression of developmental genes, normally silenced in differentiated cells. Yet, it is unclear whether such a mechanism occurs in brain cells, particularly in neurons, and whether it might contribute to neurodegenerative process, such that at play in Huntington’s disease (HD), a striatal neurodegenerative disease. In previous st
ePoster · Neuroscience