Role of PRDM2 through the prefrontal projection in stress-induced reinstatement of alcohol seeking: An epigenetic mechanism with translational potential
Kanat Chanthongdee, Tetiana Kardesh, Li Xu, Michele Petrella, Leon Höglund, Andrea Coppola, Estelle Barbier, Markus Heilig · FENS Forum 2024
In humans with alcohol use disorders (AUD), stress often triggers craving and relapse to alcohol drinking. This characteristic can be modeled in laboratory using stress-induced reinstatement. Here, we showed that in both male and female rats, an increased sensitivity to develop stress-induced reinstatement is promoted by decreased expression of Prdm2, a gene that encodes histone methyltransferase, due to alcohol-induced DNA hypermethylation in the dorsomedial prefrontal cortex (dmPFC). Consistent with our preclinical data, we found that humans with AUD had lowered PRDM2 expression in the prefr
ePoster · Neuroscience