Topic: pre- and postsynaptic pairs

How the brain processes information to learn and form memories is still a widely unanswered question. To gain insights, neurons are studied under great effort in vivo. However, the applied methods often only enable monitoring subsets of neurons embedded in a complex network or lack spatiotemporal resolution for analysis on a single-cell level. In bottom-up neuroscience, small neural networks of reduced complexity are engineered by seeding primary rat neurons or human induced pluripotent stem cell derived neurons into polydimethylsiloxane microstructures on top of microelectrode arrays (MEAs) t