Topic: pre-tangle tau

Alzheimer’s disease (AD) is believed to have a prolonged preclinical phase when aggregates of soluble, neurotoxic tau and amyloid species accrue and slowly develop into positron emission tomography (PET)-detectable neurofibrillary tangles and amyloid plaques, respectively, which in turn herald the onset of mild cognitive impairment (MCI) and dementia. Hence, understanding the spatiotemporal timeline for the accrual of these early pathological species prior to PET detection and clinical symptoms will facilitate the development of disease-modifying AD therapies. In this study, we quantified the