Topic: precerebellar nuclei

HOXA5 is a transcription factor, member of the HOX family and important player of the embryonic development. However, its postnatal role in the precerebellar nuclei of the hindbrain, its anteriormost expression domain, has not been characterized. Based on transcriptomics analysis of this specific brain region at postnatal stage, we hypothesized that HOXA5 may act as a regulator of synaptogenesis, a process involving synapse establishment and maturation. Interestingly, the early postnatal period corresponds to the window during which the precerebellar circuitry goes through synaptogenesis.In th