Inhibitory mechanisms in the dorsal anterior cingulate cortex differentially mediate putamen activity during appetitive and aversive valence-based learning
Tal Finkelman, Edna Furman-Haran, Kristoffer C. Aberg, Rony Paz, Assaf Tal · FENS Forum 2024
Learning from rewards and punishments is crucial for survival, and is mediated by interactions between the prefrontal-cortex (PFC) and subcortical structures. It is thought that inhibition plays a key role in these interactions, yet there is little direct evidence for this in humans. Here we overcome the technical challenges of measuring inhibition in the human brain and show that the primary inhibitory neurotransmitter gamma-aminobutyric-acid (GABA) differentially affects the interaction between the dorsal-anterior-cingulate-cortex (dACC) and subcortical structures during learning with reward
ePoster · Neuroscience