Topic: prefrontal neocortex

The human prefrontal neocortex has undergone dramatic expansion during evolution and is involved in decision-making, stress resistance, and behavioral flexibility. Its capacity for high-level cognition emerges from a regularly organized, six-layered structure; however, the newborn transcriptome architecture underlying layer-specific traits remains unknown. To address this complexity, we characterized the transcriptome of the six cortical layers and adjacent white matter in the dorsolateral prefrontal cortex of 5 newborns, using Visium Spatial Gene Expression kits, followed by high-resolution i