Distinct aversive states in the mouse medial prefrontal cortex.
Pierre Le Merre,Daniela Calvigioni,Janos Fuzik,Marina Slashcheva,Felix Jung,Marie Carlén,Konstantinos Meletis · COSYNE 2022
It was recently shown that glutamatergic neurons in the lateral hypothalamus (LHA) projecting to the lateral habenula (LH) encode negative value. However, it is still unclear how such aversive neuronal pathways located in subcortical neuronal populations affect the activity of the rest of the brain. We report here how the neuronal activity in an integrative cortical area previously reported to be involved in aversion, the medial prefrontal cortex (mPFC), is modulated when an internal aversive signal is emitted in the hypothalamic-habenula (LHA-LH) pathway. We have used a transgenic mouse line
Sat, Mar 19, 2022