Continued treatment of D-Pinitol ameliorates cognitive spatial flexibility of Alzheimer’s disease 5xFAD transgenic mice
Dina Medina-Vera, Cristina Rosell-Valle, Antonio J. López-Gambero, Juan A. Navarro, Carlos Sanjuan, Elena Baixeras, Patricia Rivera, Francisco J. Pavon, Fernando Rodríguez de Fonseca · FENS Forum 2024
Central insulin resistance is a typical trait associated with premature ageing and is shown in neurological illnesses such as Alzheimer’s disease (AD) in its early stages. In this sense, the (phosphoinositide 3 kinase)/Akt pathway mediates insulin signalling in the brain, where defective insulin signalling is a risk factor for developing AD. Several lines of evidence show that integrated coordination of neuronal responses through the PI3K /Akt pathway in the brain has a significant functional impact on key events that are negatively affected in AD. Moreover, the PIK3/Akt pathway is crucial in
ePoster · Neuroscience