Beyond maternal boundaries: Exploring offspring excitability in response to maternal chronic stress and mirtazapine
Alžbeta Idunková, Lucia Dubiel-Hoppanová, Katarína Ondáčová, Matúš Tomko, Bohumila Jurkovičová-Tarabová, Stanislava Bukatová, Michal Dubovický, Ľubica Lacinová · FENS Forum 2024
Maternal depression presents risks to both fetal and child development. While treating maternal depression with antidepressants during pregnancy can alleviate the condition, it also has implications for the development of the offspring. Our study aims to explore the impact of maternal depression and/or prenatal antidepressant treatment on offspring neuronal excitability.We implemented an animal model of maternal depression through chronic and unpredictable stress exposure. Mirtazapine served as the chosen antidepressant. Four experimental groups were used: no stress with vehicle, stress with v
ePoster · Neuroscience