Dietary intervention with omega-3 fatty acids mitigates maternal high-fat diet-induced depression-like phenotype and myelin-related changes in rat offspring
Irena Smaga-Maślanka, Joanna Jastrzębska, Małgorzata Frankowska, Renata Pieniążek, Julita Wesołowska, Małgorzata Filip · FENS Forum 2024
Maternal high-fat diet (HFD) during pregnancy and lactation induces depression-like phenotype and provokes myelin-related changes in rat offspring, which persist even to adulthood. Due to the plasticity of the developing brain, we decided to analyze whether depression-like phenotypes and myelin-related changes in the early lifetime induced by maternal HFD could be reversed by the omega-3 fatty acid-enriched diet (Ω3D). We investigated the effects of the Ω3D from the post-weaning period until adulthood (63rd day of life) in offspring on the depressive-like behavior (forced swimming test, locomo
ePoster · Neuroscience