Modification of cognitive development in offspring born to pregnant dams with IBD-like gut pathology induced at mid-gestation
Jimmy Lam, Marcus H.F Ng, Vic K.T Sun, K. M Cheng, Amber H Yang, Benson W.M Lau, William C.S Tai, Benjamin K Yee · FENS Forum 2024
Inflammatory bowel disease (IBD) is associated with inflammatory activity in the GI tract and birth complications in pregnant women. The long-term impact of gestational IBD on offspring development, however, has not been examined. Here, we employed dextran sulfate sodium (DSS, 2.5% in drinking water on GD9-12) to induce colonic mucosa ulceration to the pregnant C57BL/6 mice dams. Offspring from DSS-treated dams were compared with non-treated dams at juvenile (PND 30) and adult age (PND 70) in behavioural tests sensitive to the acute gestational infection induced by polyinosinic:polycytidylic a
ePoster · Neuroscience