Preoptic PNOC neurons modulate energy expenditure and adipose tissue function
Adel Ben-Kraiem, Anton Ilango Micheal, Hans Ulrich Zeilhöfer, Jens Brüning, Nora Klöting, Matthias Blüher, Alexander Jais · FENS Forum 2024
The preoptic area (POA) of the hypothalamus has garnered attention regarding its pivotal role in energy balance control and thermoregulation. Activation or inhibition of specific POA neurons has been shown to affect body temperature, locomotor activity and energy expenditure. To gain novel insights into this regulatory mechanism, we have conducted a comprehensive analysis of a distinct neuronal cluster within the POA that express the neuropeptide prepronociceptin (PNOC). Using chemogenetic techniques, we selectively activated PNOC(POA) neurons of mice and observed a significant reduction in br
ePoster · Neuroscience