Topic: presynaptic GlyRs

Glycine receptors (GlyRs) are crucial for the balance of excitation and inhibition in the mammalian spinal cord and brain stem. They belong to the superfamily of Cys-loop receptors and form pentameric ligand-gated chloride channels consisting of postsynaptic αβ heteromers or α homomers located extrasynaptically and at presynaptic membranes. Presynaptic GlyRs trigger depolarizing chloride currents upon activation by glycine spill-over.Autoantibodies (aAbs) against GlyRs are associated with the autoimmune disease Stiff Person Syndrome but also frequently found in patients with focal epilepsy. Lo