Topic: presynaptic homeostatic plasticity

Monocular deprivation-induced ocular dominance plasticity (MD-ODP) in the visual cortex is an established in vivo paradigm, in which inactivity-induced synaptic plasticity contributes to the functional reconfiguration of cortical networks. Bassoon (Bsn) is a presynaptic protein involved in the spatial and functional organisation of synaptic vesicle (SV) recycling. Here, we report a novel role for Bsn in the inactivity-induced functional reconfiguration of adult neocortical networks in vivo and in vitro. We subjected Bsn knock-out mice to MD and imaged visual stimulus-evoked intrinsic signals i