Topic: presynaptic inputs

The cerebellum critically contributes to motor, cognitive and emotional functions. Cerebellum-dependent motor learning is believed to be processed within the cerebellar cortex, and specifically via changes in synaptic plasticity of Purkinje cells (PCs), which are the main cortical output. However, whether and how motor learning can influence the actual connectivity of PCs is unknown. To address this question, we use a rabies virus (RABV)-based approach to map structural modifications of PC presynaptic inputs in young (3-month-old) and middle-aged mice (1-year-old). To promote motor skill learn