Topic: presynaptic mitochondria

The post status epilepticus (SE) model is one of the most helpful animal models for epilepsy research. In many cases it closely mimics the clinical signs of temporal lobe epilepsy in humans. Although behavioral, electrophysiological and molecular alterations following SE have been extensively studied, corresponding structural changes remain less well explored. However, to optimize the treatment of epilepsy and complications of SE, it is essential to know how effectively they prevent seizure-induced neuronal damage. In the present study, we elucidate ultrastructural changes and quantitative alt