Topic: presynaptic precursor vesicles

Synapse formation, maintenance and function requires a continuous material supply from the neuronal soma, the site of protein production. Presynaptic material is suggested to traffic on highly specialised and diverse membranous organelles, the presynaptic precursor vesicles (reviewed in Petzoldt, Cells, 2023). Molecular mechanisms controlling their assembly and transport remain poorly understood. We could show that the small GTPase Rab2 is required in a Golgi-associated assembly sequence during early presynaptic precursor biogenesis (Götz … Sigrist, Petzoldt, JCB, 2021). Upon Rab2 depletion, b