Topic: primary visual cortex V1

Astrocytes are the most abundant glial cell type in the central nervous system. They express G-protein-coupled receptors (GPCRs), which respond to inflammatory and stress mediators. Activation of astrocytic GPCRs triggers elevation in intracellular calcium levels and the production and release of astrocytic factors. These astrocytic factors play crucial roles in modulating synapse numbers and synaptic plasticity.Changes in synapse numbers have been documented in neurodevelopmental disorders (NDDs). Many epidemiological studies indicate that chronic inflammation and stress during critical neuro