Brainstem serotonin neurons selectively gate retinal information flow to thalamus
Mark Andermann, Andrew Lutas, Liang Liang, Jesseba Fernando, Jasmine Reggiani, Melanie Barbini, Qiufen Jiang, Fei Deng, Jinxia Wan, Yulong Li, Chinfei Chen · COSYNE 2023
Retinal ganglion cell (RGC) types relay parallel streams of visual feature information. We hypothesized that neuromodulators might efficiently control which visual information streams reach the cortex, by selectively gating transmission from specific RGC axons in the thalamus. Using fiber photometry recordings, we found that optogenetic stimulation of serotonergic axons in primary visual thalamus of awake mice suppressed ongoing and visually evoked calcium activity and glutamate release from RGC boutons. Two-photon calcium imaging revealed that serotonin axon stimulation suppressed RGC boutons
Fri, Mar 10, 2023