Early movement restriction affects the acquisition of neurodevelopmental reflexes in rat pups
Orlane Dupuis, Mélanie Van Gaever, Valérie Montel, Julie Dereumetz, Jacques Olivier Coq, Marie Hélène Canu, Erwan Dupont · FENS Forum 2024
Childhood is a period of construction of the organism, during which interactions with the environment and regular physical activity favour the maturation of the neuronal networks. However, some children exhibit a sensorimotor restriction (SMR) because they are bedridden or they suffer from a neurodevelopmental disorder. In order to better understand the emergence of neuromuscular disorders in these children, a model of SMR has been developed in rats, consisting in hindlimb casting from postnatal day (PND) 1 to PND 28. These animals display a prominent motor phenotype that includes muscle weakn
ePoster · Neuroscience