Early-career industrial chemists present research from pharmaceutical, biotechnology and agrochemical settings, connecting academic chemistry with the practical constraints of industrial discovery and development. The programme examines digital route design for KRAS inhibitors, principal-component analysis of pharmaceutical oils, antibody modification by sulfur(VI)-fluoride exchange, photochemical oligonucleotide synthesis, flow photoredox chemistry, molecular-glue synthesis and ERAP1 inhibitor discovery. A closing keynote considers digital strategy in industrial chemistry. Talks include discu
ePoster · Neuroscience
Cortex-wide high density ECoG recordings from rat reveal diverse generators of sleep-spindles with characteristic anatomical topographies and non-stationary subcycle dynamics
Arash Shahidi, Ramon Garcia-Cortadella, Gerrit Schwesig, Anna Umurzakova, Mudra Deshpande, Ekaterina Sonia, Anton Sirota · Bernstein Conference 2024
Accumulating evidence from electrocorticogram (ECoG) recordings and imaging challenge traditional views of brain oscillations as spatially stationary periodic sources. Understanding the spatio-temporal dynamics of cortical activity requires novel measurement and analysis methodologies. We recorded broadband local field potential (LFP) across the whole neocortex in freely behaving rats using high-density flexible surface arrays using active transistors. 3D tracking and spatio-spectral analysis of recordings over long sessions enabled automatic and accurate brain and behavioral states segmentati