Investigating prefronto-striatal circuit dynamics during flexible decision-making
Aron Koszeghy, Alexander Wallerus, Sofia Castro e Almeida, Arsenii Petryk, Moritz Henninger, Maja Überegger, Johannes Passecker · FENS Forum 2024
Cognitive flexibility is critical for enabling humans and animals to maintain and maximize rewarding outcomes in a changing environment, and often compromised in various psychiatric conditions including Schizophrenia (Lotus Thai, et al, 2019; Zhu, Ho-wai So, et al, 2021). Prefrontal cortex (PFC) and basal ganglia (BG) are both important brain systems in establishing and switching between flexible goal-directed strategies, and repetitive behaviours (Merre, et al, 2018; Hart, Balleine et al, 2014). The direct anatomical connection between PFC and striatum (STR; the input nucleus of BG) is consid
ePoster · Neuroscience