Topic: prodromal mouse model

Although Parkinson's disease (PD) is becoming increasingly important in ageing societies, its diagnosis still relies on the presence of classical motor symptoms that usually manifest in the later stages of the disease's progression. Patients may, however, present non-motor signs as cognitive and/or mood issues years prior to the onset of the motor ones. The Locus Coeruleus (LC) is one of the first areas to exhibit Lewy bodies and neurodegeneration. Its dysfunction is associated to the appearance of nonmotor symptoms due to its noradrenergic (NA) projections and influence on the homeostasis of