Topic: proinflammatory cytokine IL-1

Parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, leading to a spectrum of motor and non-motor symptoms. While motor deficits serve as the primary criteria for diagnosis, emerging evidence suggests that non-motor symptoms may also significantly contribute to the disease's progression. In this study, our aim was to investigate the potential impact of IGF-1 on the progression of emotional-like behavioral deficits in a rat model of neurotoxicity induced by 6-OHDA infusion into the dorsolateral striatum. We evaluated behavioral chang