Rptor/mTORC1 function in radial glia progenitor lineage progression
Ana Villalba Requena, Robert Beattie, Florian M. Pauler, Carmen Streicher, Thomas Krausgruber, Martin Senekowitsch, Matthias Farlik, Christoph Bock, Thomas Rülicke, Simon Hippenmeyer · FENS Forum 2024
The cerebral cortex is composed of an extraordinary number of neuronal and glial cell types assembling into cortical circuits that account for cognitive abilities. Remarkable heterogeneity in the spectrum of cortical cell types has been described on the basis of global transcriptome analysis. How cell-type diversity is generated by radial glia progenitor (RGP) cells during development is however still poorly understood. Here we focus on the Rptor/mTORC1 signaling pathway and its role in RGP cell lineage progression and cortical neurogenesis. By using Mosaic Analysis with Double Markers (MADM)
ePoster · Neuroscience