Projections from the medial prefrontal cortex to the ventral midline thalamus are crucial for cognitive flexibility in rats
Elodie Panzer, Laurine Boch, Brigitte Cosquer, Anne Pereira de Vasconcelos, Aline Stéphan, Jean-Christophe Cassel · FENS Forum 2024
Cognitive flexibility is the capability to appropriately adapt one's behavior in response to new and unexpected conditions in the environment (Prado et al., Neuroscience, 2017). This cognitive function plays a fundamental role in our ability to adapt and learn. When cognitive flexibility encompasses spatial information, it is supported by a hippocampo-cortico-thalamic network in which the reuniens and rhomboid nuclei (ReRh) of the thalamus may relay information between hippocampus and the medial prefrontal cortex (mPFC). We showed that reversible inactivation (muscimol or DREADD for ReRh) of o
ePoster · Neuroscience