Topic: projection-specific populations

Memories are known to initially depend on the hippocampus for their expression but become more dependent on the medial prefrontal cortex (mPFC) at remote time-points. Although the retrieval-induced activity of mPFC increases with time, it is unclear whether distinct mPFC projection-specific populations (PSPs) contribute to retrieval at different time points. Here, delineate how these distinct PSPs contribute to memory expression at recent vs. remote time-points. We virally labeled PSPs and examined the extent to which they are reactivated during recent vs. remote recall. Then, we used optogene