Behavioural control training promotes antidepressant/anxiolytic-like reversal of chronic stress-induced behavioural deficits: Endocannabinoidergic and prolactinergic mechanisms
Francis Bambico, Andrew MacPherson, Tadhg Strand, Gavin Afonso, Courtney Clarke, Shannon Waye, Nageeb Hasan, Caio Oliveira, Matheus Cravatti, Jose Nobrega · FENS Forum 2024
A cognitive model of stress posits that psycho-affective disorders can arise from a perceived lack of stress control. Uncontrollability is linked to perturbed prefrontocortical (PFC)-limbic signalling of endocannabinoids (anandamide) and altered hormonal activity (prolactin and glucocorticoids). Behavioural therapies such as cognitive-behavioural/remediation therapies ameliorate symptoms by enhancing perceived controllability. There is also evidence that augmenting endocannabinoid and hormonal levels results in antidepressant/anti-stress action. Based on a modified version of the rodent Morris
ePoster · Neuroscience