Selective estrogen receptor agonists confer minimal protection from global cerebral ischemia but show impacts on anxiety-like behaviors and microglial activation
Marilou Poitras, Alexandra Doiron, Kathya Daniela Díaz García, Balsam Ben Hamed, Madison Lebeau, Hélène Plamondon · FENS Forum 2024
Global cerebral ischemia (GCI) causes extensive neuronal injury and significant behavioural impairments. Although these sequelae can be mitigated by selective activation of estrogen receptors (ERs), their influence on inflammatory processes mediated by microglial activation are not fully understood. This study characterized the impact of selective ER activation on post-ischemic anxiety-like behaviours and microglial activation. 46 adult female Wistar rats were ovariectomized and, starting the following day, received daily subcutaneous injections of propylpyrazole triol (ERα agonist), diarylpro
ePoster · Neuroscience