Neuromodulators trigger the formation of inhibitory boutons in hippocampus via activation of cAMP/PKA signaling
Ségolène Bompierre, Seeger Deerenberg, Iris Westerdiep, Gisela Espriu Aguado, Bart Jongbloets, Corette Wierenga · FENS Forum 2024
The formation of new inhibitory synapses is essential to counterbalance a strong excitatory activity and maintain dendritic coordination between excitation and inhibition. We recently demonstrated that the activation of excitatory spines is followed by the production of endocannabinoids in dendrites, which mediates the formation of new inhibitory boutons via axonal CB1 receptors. Bouton formation was found to depend on an increase of the second messenger cyclic adenosine monophosphate (cAMP) and the activation of the downstream protein kinase A (PKA). We ask whether other neuromodulators are a
ePoster · Neuroscience