Topic: protein kinase C gamma

Spinocerebellar ataxias (SCAs) are characterized by cerebellar atrophy and the degeneration of Purkinje neurons resulting from mutations in various genes. Specifically, in SCA14, the disease is caused by point mutations or deletions in the protein kinase C gamma (PKCγ) gene. PKCγ is a serine/threonine kinase predominantly expressed in cerebellar Purkinje cells, and plays a crucial role in the regulation of synapse formation and dendritic development of Purkinje cells. However, the precise mechanisms underlying these processes are not fully understood yet. In this project, our aim is to investi