Topic: proteome remodeling

Learning relies on neuronal plasticity through the dynamic modification of proteome repertoire. Among the mechanisms that trigger proteome remodeling, activity-dependent transcription and -translation programs have been shown to be essential for learning and memory. Yet, alternative splicing is the main driver of proteome diversification and its regulation emerges to dramatically impact the neuronal proteome upon stimulation. Surprisingly, its role in learning and memory remains largely unexplored. In this study, we show that the kinase CLK1, a pivotal regulator of alternative splicing, is reg