Topic: PSD-95 KO mice

Repetitive cocaine exposure induces the generation of silent synapses in the nucleus accumbens, characterized by the presence of NMDA receptors and absence of AMPA receptors, hindering fast synaptic transmission (Huang et al, 2009). While typically abundant during early postnatal development, cocaine triggers the de novo generation of silent synapses in the adult brain, thereby establishing new synaptic connections within an already refined circuit (Huang et al, 2009; Huang et al, 2015). During withdrawal, some silent synapses undergo unsilencing by incorporating AMPARs, which crucially contri