Study the role of microglia in Alzheimer’s disease with human iPSC-derived microglia cells
Coralie Clua Provost, Eliot Schob, Meline Antunes, Cécile Monzo, Hélène Hirbec, Carole Crozet · FENS Forum 2024
Microglia, tissue-resident macrophages of the brain, are strongly involved in the maintenance of brain homeostasis. Genome-wide association studies have established their critical role in the pathogenesis of Alzheimer’s disease (AD) but their precise contribution is not yet clarified. Most AD preclinical studies are performed in transgenic mouse models. However murine and human microglia have different transcriptomic profiles with aging. Interestingly, induced pluripotent stem cells (iPSCs) – derived models enable studying human-like cells. Our project aims to generate human iPSCs-derived micr
ePoster · Neuroscience