Topic: PSEN1M146V

Among the three ApoE isoforms, ApoE4 is a major risk factor for sporadic AD due to its impact on amyloid beta (Abeta) clearance and plaque formation. Although extensive research has connected ApoE to various AD-related pathologies beyond Abeta, its association with ApoE isoforms remains an area that requires further investigation. This study aimed to elucidate the effects of ApoE isoforms on AD pathology using human ApoE Knock-In (KI) AD mouse models. First, we generated an APPNL-G-F;hApoE (ApoE Double KI) mouse model by crossing human ApoE3 or ApoE4 KI mice with APPNL-G-F KI mice. Additionall