Topic: psychomotor activation

Dopamine release in the striatum is crucial for motor control, as exemplified by psychomotor activation elicited by dopamine-mimetic drugs and motor deficits in Parkinson’s disease upon the degeneration of dopaminergic axons in the striatum. Evidence indicates that meso-striatal dopamine activity supports motion vigor and/or exhibits “chunking”, a movement-bracketing activity pattern related to movement initiation and termination. However, the role of striatal dopamine during movement, especially in the absence of rewards, remains insufficiently understood. Here, we investigated dopamine relea