Application of dehydroepiandrosterone as a neuroprotective agent for the therapy of Alzheimer’s disease in a mouse model
Kvak Erika Eliza, Szidónia Farkas, Adrienn Szabó, Dóra Zelena · FENS Forum 2024
Alzheimer's disease (AD) is one of the most significant neurodegenerative diseases, and its effective treatment remains a challenge. Dehydroepiandrosterone (DHEA) is an androgen molecule, which in vitro protects against amyloid-ß (Aß) toxicity, and so might potentially improve cognitive functions. As steroid might influence wide range of processes both short (via membrane receptors) and long term (via intracellular receptors) we can expect beneficial effect already after one injection.Six months old male 3xTg-AD mice were treated intraperitoneally with DHEAS (a water-soluble sulphate salt of D
ePoster · Neuroscience