Multipotent progenitors instruct ontogeny of the superior colliculus
Giselle Cheung, Florian M. Pauler, Peter Koppensteiner, Thomas Krausgruber, Carmen Streicher, Martin Schrammel, Natalie Gutmann-Özgen, Alexis E. Ivec, Christoph Bock, Ryuichi Shigemoto, Simon Hippenmeyer · FENS Forum 2024
The superior colliculus (SC) is a dorsal midbrain structure known for its roles in multisensory integration and motor responses and its dysfunction has been linked to neurodevelopmental diseases. SC is a highly organized structure composed of distinct laminae of diverse neuronal and glial cell types. However, the precise developmental principles instructing the generation of SC cell-type diversity are still unknown. To investigate this, we pursued lineage tracing using genetic MADM (Mosaic Analysis with Double Markers)-based clonal analysis with single cell sequencing (MADM-CloneSeq) and in si
ePoster · Neuroscience