Involvement of tyrosine kinase Pyk2 in synaptotoxicity associated with Alzheimer’s disease: A protein at the interface of amyloid and Tau pathologies
Quentin Rodriguez, Eve Borel, Sylvie Boisseau, Karina Vargas-Baron, Floriane Payet, Béatrice Blot, Mireille Albrieux, Alain Buisson · FENS Forum 2024
Alzheimer's disease (AD) is characterized by an early hippocampus hyperactivity triggered by Aβ oligomers (Aβo) in humans and AD mouse models, followed by hypoactivity and synaptic loss occurring before cognitive decline. GWAS identified PTK2B gene encoding for Pyk2, a tyrosine kinase involved in synaptic plasticity, as a new AD risk factor. Several studies have validated Pyk2 involvement in AD pathophysiology, but its exact role is still debated due to conflicting results. The objective of this project is to decipher the role of Pyk2 in synaptic dysfunctions observed in this disease. We first
ePoster · Neuroscience