Topic: pupil size fluctuations

Arousal state has a major impact on perceptual ability, task performance, and diverse aspects of physiology and behavior. During wakefulness, spontaneous fluctuations in arousal state strongly modulate neural activity in numerous brain regions in mice, but the lack of large-scale, deep imaging methods has prevented testing whether these fluctuations affect the entire brain uniformly. Moreover, it remains unclear whether spontaneous and sensory-evoked fluctuations in arousal state engage the same brain circuits or are fundamentally distinct processes. To address this gap, we used functional ult