The neurophysiological mechanisms of impaired manual dexterity in Parkinson's disease: A multimodal study using PET/CT, EEG, and BDNF
Karolina Lorek, Joanna Mączewska, Leszek Królicki, Małgorzata Chalimoniuk, Józef Langfort, Sławomir Budrewicz, Magdalena Koszewicz, Łukasz Szumowski, Jarosław Marusiak · FENS Forum 2024
The neurophysiological mechanisms of impaired manual dexterity in Parkinson’s disease (PD) have not been elucidated. Hence, our study aimed to compare healthy subjects (HCO) and mildly affected PD patients and to evaluate associations between parameters: (i) striatal dopaminergic function; (ii) activity of the motor cortex; (iii) brain-derived neurotrophic factor (BDNF) and (iv) manual dexterity.The study involved fifteen HCO subjects and thirty patients with mild PD. All subjects were assessed by: (i) Positron Emission Computed Tomography with estimation of striatal [18F]Fluorodopa uptake rat
ePoster · Neuroscience