Screening for novel modulators of hP2X2 and hP2X4 receptors using an in silico approach
Pamela Godoy, Oscar Ramírez-Molina, Rocío García-Campillay, Camila Millar-Obreque, Carlos Felipe Burgos · FENS Forum 2024
Purinergic P2X receptors (P2XR) are activated by ATP, with 7 different subunits capable of forming homo- or heterotrimeric channels. Widely expressed in the nervous system, P2XR have been implicated in neurological diseases, such as Alzheimer's disease, where overexpression of P2X2, P2X4 and P2X7 is observed. Despite decades of research into their function and structure, few P2XR structures and specific negative modulators have been described. Human P2X2 (hP2X2) and P2X4 (hP2X4) structures are not available, posing challenges for designing more effective and specific modulators.In this study,
ePoster · Neuroscience