Simple mathematical model for replicating the ATP-induced Ca2+ transients in different types of cochlear supporting cells
Eszter Berekméri, Fruzsina Fazekas, Louise Moysan, Ann-Kathrin Lutz, János Farkas, Adam Fekete, László Köles, Beáta Sperlágh, Tibor Zelles · FENS Forum 2024
Supporting cells of the hearing organ are studied mostly in young and still deaf rodents. The receptors of the purinergic system is spread in the supporting cells and their roles in spontaneous activity during the development has been recognized, but our knowledge about the presence and role in older mice is much sparse.We have investigated the ATP induced Ca2+ transients with both experimental and modeling approaches.ATP-evoked Ca2+ responses were measured in Deiters’ (DCs), Hensen’s (HCs) and Claudius’ cells (CCs) in the BALB/c mouse hemicochlea preparation (from 14 days old to 21 days old).
ePoster · Neuroscience