Dlx5/6 involvement in the postnatal maturation of cortical parvalbumin neurons during critical periods
Lou Belz, Rym Aouci, Amïn Vion, Anastasia Fontaine, Giovanni Levi, Nicolas Narboux-Nême · FENS Forum 2024
Brain activity depends on GABAergic inhibitory interneurons. Dlx5 and Dlx6 are two closely related homeobox genes, expressed by the telencephalic ganglionic eminences. In the adult brain, Dlx5/6 are expressed in most cortical GABAergic interneurons.In the prefrontal cortex, Parvalbumin-positive neurons (PV-neurons) are involved in cognitive functions, and their maturation is critical for cognitive development. Using mouse lines in which Dlx5/6 are either invalidated or overexpressed in GABAergic neurons, we have recently shown that the adult density of PV-neurons is directly correlated to Dlx5
ePoster · Neuroscience