Topic: PV suppression

We investigated the role of GABAergic parvalbumin-expressing (PV) interneurons in the hippocampus in spatial and hippocampus-dependent memory abilities in rat models of Parkinson's disease (PD). Experiments were performed in adult male Wistar rats, including physiological controls(n=14) and toxin lesion-induced PD models: PD cholinopathy(n=10), hemiparkinsonism(n=7), and hemiparkinsonism with PD cholinopathy(n=6). Behavioral assessments and PV immunohistochemistry were performed 14 and 42 days after the lesions. Spatial and hippocampus-dependent short- and long-term memory were assessed with t