Topic: PV-to-E short-term depression

Inhibitory neurons in the cortex are highly diverse in terms of anatomy, electrophysiology and functions. In the mouse cortex, three major classes of interneurons expressing parvalbumin (PV), somatostatin (SST) and vasoactive intestinal peptide (VIP) constitute more than 80% of GABAergic interneurons. Together with excitatory (E) neurons, they form a canonical microcircuit relevant for cortical computations. Multiple experimental studies have revealed that this canonical microcircuit can exhibit counterintuitive nonlinear behavior. More specifically, the circuit can perform response reversal w