Fluorescent drug conjugates for imaging the serotonin transporter
Oliver Belleza, Iakovos Saridakis, Nadja Singer, Xavier Westergaard, Sergio Armentia Matheu, Miran Lemmerer, Margaux Riomet, Pedro Sanchez-Murcia, Nina Kastner, Stefanie Rukavina, Yi Xiao, Kathrin Jaentsch, Marco Niello, Klaus Schicker, David Sulzer, Leticia Gonzalez, Nuno Maulide, Harald Sitte · FENS Forum 2024
Fluorescent drug conjugates enable the selective visualization of proteins in cell models, primary cultures, and tissue preparations. These compounds have become valuable tools in neuroscience in investigating the expression and function of ion channels, receptors, and transporters. In this project, we explored the utility of fluorescent drug conjugates in visualizing the serotonin transporter (SERT) in the brain. We made use of a recently developed class of fluorescent compounds called PyrAtes which offer interesting chemical properties, photostability, and large Stokes shifts. Herein, two co
ePoster · Neuroscience